Risk of cancers assessed by the modified intention to treat model and by the per protocol model.

Abbreviations: mITT, modified intention to treat; NDA, New drug Approval; NMSC, non-melanoma skin cancers; OR, odds ratio; 95% CI, 95% confidence interval;
*14 trials included for overall cancer analysis.
†7 trials included for overall cancer analysis.
‡The trial by Miyasaka et al. was excluded from these analyses for the two cancers that occurred in the placebo arm were not otherwise specified.
§These analyses excluded two trials: the one by Miyasaka et al. (because the two cancers that occurred in the placebo arm were not otherwise specified) and the one by Weisman et al. (because the three skin cancers that occurred were not otherwise specified).
¶Publication bias.