Cardiopulmonary Phenotyping of Sex-Based Differences in a Feline Model of HFpEF

In order to better understand sex-related differences of heart failure with preserved ejection fraction (HFpEF), male and female kittens underwent aortic contriction surgery (banding) or sham surgery (normal). Slow progressive pressure overload was then compared between male and female kittens, analyzing structural and functional phenotypes. Transcriptional differences between male and female kittens were investigated via single nuclear RNA sequencing (snRNA-seq) within left ventricle tissue. Overall design: Compared transcriptional differences in left ventricles between male and female kittens when placed under aortic constriction (banding)