Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) table for Trachea, v1.0

Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) tables (https://humanatlas.io/asctb-tables) aim to capture<br>the nested trachea structure of anatomical human body parts, the typology of cells, and biomarkers used to identify<br>cell types. The tables are authored and reviewed by an international team of experts. The Trachea ASCT+B table v1.0<br>was developed following the revisions of the Lung ASCT+B tables (v1.2–1.3), during which the Trachea and Main Bronchus<br>were delineated into separate tables. This table focuses on the anatomical structures, cell types, and biomarkers<br>specific to the human trachea. With the assistance of Joshua Fortriede, Ellen Quardokus, and Aleix Puig Barbe (EBI),<br>updates were made to Uberon and the Cell Ontology, including the addition and revision of terms as necessary.<br>Relationships among anatomical structures (AS-AS), anatomical structures and cell types (AS-CT), and among cell types<br>(CT-CT) were corrected and verified. Gene markers were reviewed and updated based on recent single-cell RNA sequencing<br>(scRNAseq) lung cell type references. A description of this Trachea ASCT+B table can be found in "Anatomical<br>Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas" by<br>(Börner et al. 2021). The database and code used to generate the more simplified view of the Trachea in these ASCT+B<br>tables may be found here<br>(https://github.com/hubmapconsortium/hra-vccf). <br><br>**Bibliography:**<br><br>* Börner, Katy, Sarah A. Teichmann, Ellen M. Quardokus, James C. Gee, Kristen Browne, David Osumi-Sutherland, Bruce W. Herr II, et al. 2021. “Anatomical Structures, Cell Types and Biomarkers of the Human Reference Atlas.” *Nature Cell Biology* 23 (11): 1117–28. https://doi.org/10.1038/s41556-021-00788-6.