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Mutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway
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2025-01-24
相关数据集
MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway [bulkRNA-seq]. MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway [bulkRNA-seq]
The microRNA (miR) miR-874, a potential tumour suppressor, causes cell death via target gene suppression in various cancer types. Mevalonate pathway inhibition also causes cell death in breast cancer.
NIAID Data Ecosystem30
RNA-seq of S. cerevisiae S288C wild-type and S288C-H2 mutant
S. cerevisiae strain S288C was subjected to CRISPR/Cas9 edition in the HMG-CoA reducatase gene using a modified housekeeping promoter ADH1 incorporating the up-stream region of TEF1 promoter (UADH1).
NIAID Data Ecosystem20
Additional file 3 of Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway
Supplementary Material 3
Figshare2025-03-05 更新10
ePoster Vascular Discovery 2020 MDG.pdf
Hmg-CoA Reductase (Hmgcr) catalyzes the conversion of Hmg-CoA to mevalonate, which is the rate-limiting step in the cholesterol biosynthetic pathway. Hmgcr is the target of statins, which are the fron
HRA Figshare2026-05-15 更新20
Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase
Regulation of the sterol-synthesizing mevalonate pathway occurs in part through feedback-regulated endoplasmic reticulum degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R). In yeast, the
PubMed Central1997-11-25 更新10
