Synthesis of α‑Carbonyl-α′-amide Sulfoxonium Ylides from Isocyanates with Complete Atom Economy

An efficient catalyst- and additive-free facile synthesis
of α-carbonyl-α′-amide
sulfoxonium ylides from isocyanates and β-ketosulfoxonium ylides
with complete atom economy has been described. The β-ketosulfoxonium
ylides and isocyanates adorned with various functional groups were
well-tolerated and afforded moderate to high yields of the α-carbonyl-α′-amide
sulfoxonium ylide derivatives. Finally, using large-scale reactions
and converting the synthesized ylides into other valuable compounds,
we demonstrated the practicality of this synthetic method.