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Defective Mitophagy in XPA via PARP1 activation and NAD+/SIRT1-depletion: Implications for neurodegeneration

NIAID Data Ecosystem2026-03-11 收录

神经退行性机制

SIRT1

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE55486 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2020-06-22

神经退行性机制

细胞应激通路

Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathw

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Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology [14 months]

神经退行性机制

胶质细胞功能研究

GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyp

NIAID Data Ecosystem30

A Coarse-Grained MD Model for Disorder-To-Order Transitions in PolyQ Aggregation

蛋白质聚集

神经退行性机制

Polyglutamine (polyQ) aggregation plays a central role in several neurodegenerative diseases, including Huntington’s disease. To investigate the underlying mechanisms of polyQ aggregation, we develope

Figshare20

AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons. AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

神经退行性机制

功能障碍研究

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

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Fecal microbiota transplantation derived from Alzheimer's disease mice worsens brain trauma outcomes in young C57BL/6 mice

神经退行性机制

脑损伤研究

Traumatic brain injury causes neuroinflammation and neurodegeneration, which increase the risk and accelerate the progression of Alzheimer disease. The gut microbiome is an essential modulator of the

NIAID Data Ecosystem30

Defective Mitophagy in XPA via PARP1 activation and NAD+/SIRT1-depletion: Implications for neurodegeneration

资源简介：

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