Metagenome analysis of fungal and bacterial blood microbiome in healthy indiviuals. Human blood microbiome

On the analogy of the non-pathogenic microbiota found in oral cavity, skin and gastrointestinal tract, existence of blood microbiota was confirmed by DNA sequencing, but never deeply characterized. Hypothesis for the existence of dormant blood microbiota in healthy humans have been arisen and single species have been isolated. The aim of our study was to resuscitate and investigate the biodiversity of bacterial and fungal dormant blood microbiota in healthy individuals by blood culturing and NGS DNA sequencing. Analysis for bacterial and eukaryotic species was performed by 16S rRNA and ITS2 targeted sequencing.