Insights from metagenomics into gut microbiome associated with acute coronary syndrome therapy. human gut metagenome

Acute coronary syndrome (ACS) is a predominant cause of mortality, and the prompt and precise identification of this condition is crucial to minimize its impact. Recent research indicates that gut microbiota is associated with the onset, progression and treatment of ACS. To investigate its role, we sequenced the gut microbiota of 38 ACS patients before and after percutaneous coronary intervention and statin therapy at three time points, obtaining approximately 22 billion usable reads and examining differential species, genes and metabolic pathways.