Screening of angiogenesis effects for tanshinone derivatives in VRI-induced blood vessels loss zebrafish embryos.

The semi-quantitative scale for restorative blood injury rates of compounds 1–11 and three tanshinones: ○, inactive; +++++, > 80% restorative rate; ++++, 60–80%; +++, 40–60%; ++,20%–40%; +< 20% restoration for ISVs as compared to the vehicle treated zebrafish embryos. aZebrafish embryos treated with the indicated concentration of compound were dead. bZebrafish embryos treated with the indicated concentration of compound were toxic and the effect was not determined.