The data from pharmacokinetic studies refer to healthy volunteers (n = total number of volunteers) with data on bioavailability (f), apparent total clearance (CL<sub>t</sub>/f) and its standard deviation (SD), average elimination half-life (t<sub>½</sub>), the mean dose related concentration (DRC) factor with its lower limit for two time intervals between last dose and blood sampling (Δt).
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For other values of Δt the formulas below have to be employed. The last column cites the therapeutic reference range as retrieved from Schulz et al. [19].
创建时间：
2020-08-10
