Src protein tyrosine kinase phylogeny

Best of 50 ML trees as inferred by RAxML under the LG+ Γ model (see STAR methods). Purple, pink, orange, blue, light blue and brown texts indicate C. owczarzaki, M. vibrans, Pigoraptor (strains Opistho-1 and Opistho-2), S. multiformis
(strain Colp-12), C. limacisporum and H. sapiens, respectively. The query sequence is indicated in red. A shaded rectangle indicates the protein in question in filastereans and Pluriformea. An asterisk indicates annotated human proteins belonging to the Src family. Other protein tyrosine kinases (Tec, Abl2 and Csk) are indicated and were identified by the annotated C. owczarzaki homolog present in the respective clade. Node supports are nonparametric ML bootstrap values obtained from 1000 ML replicates using the LG+Γ model implemented in RAxML, numbers at nodes represent bootstrap supports of greater than 50%. The scale bar represents the estimated number of amino acid substitutions per site.