A Small Molecule Activator of the TET2 Tumor Suppressor
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https://www.ncbi.nlm.nih.gov/sra/SRP166152
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资源简介：
TET2 protein is a dioxygenase that oxidizes 5-methylcytosine and is responsible for DNA demethylation. We found that a small molecule drug (3FM-dC) activates the enzyme activity of TET2. The sequencing data suggest that 3FM-dC induced global changes in DNA hydroxymethylation and gene expression. Overall design: To determine the effects of 3FM-dC on global gene expression, we performed RNA-seq on control and 3FM-dC treated K-562 cells.
创建时间：
2022-11-11
