Plant virus database (PVirDB)

This is a custom-built blast database of higher plant viruses and viroids.

A challenge associated with the bioinformatics analysis of sequencing data for diagnostic purposes is the dependency on sequence databases for taxonomic assignment of detection. Although public databases such as the GenBank database maintained at NCBI are the most up to date, the enormous nature of these databases limits their portability across different computing resources. Moreover, sequencing data submitted by users to these public databases may not be accurate, and annotations provided in the GenBank record, such as the taxonomy assignment, which is crucial for accurate diagnosis, may be inaccurate and/or out of data. Additionally, the descriptors of the sequences in the public databases are not harmonized and lack taxonomic information posing an additional challenge to validate sequence homology-based pathogen detections.

本数据集为针对高等植物病毒与类病毒（viroids）定制构建的BLAST（局部序列比对基本工具）数据库。
用于诊断用途的测序数据生物信息学分析，存在一项核心挑战：检测结果的分类学归属高度依赖序列数据库。尽管由美国国家生物技术信息中心（NCBI）维护的GenBank等公共数据库是当前最前沿的序列资源，但其体量过于庞大，限制了在不同计算环境下的可移植性。此外，用户提交至公共数据库的测序数据可能存在准确性缺陷；GenBank记录中的注释信息，例如对精准诊断至关重要的分类学归属标注，也可能存在不准确或过时的问题。除此之外，公共数据库中序列的描述信息未实现统一规范，且缺乏分类学相关信息，这为基于序列同源性的病原体检测结果验证带来了额外挑战。