RNA and single-cell RNA sequencing of murine cardiomyocyte and single-cell RNA sequencing of murine CD45+cells in the early phase of heart failure

In this study, we explore a dynamic interplay between cardiac CD8+T cells and macrophages that is necessary for adaptation to cardiac stress, highlighting the homeostatic functions of resident and infiltrated macrophages in the heart. To understand transcriptomic differences of the heart, we performed RNA sequencing and single-cell RNA sequencing (scRNA-seq) analysis on cardiomyocytes. To understand transcriptomic differences of the immune cell populations in the heart, we performed scRNA-seq analysis on CD45+ immune cell populations.