Single-cell transcriptional profiles of lung CD45+ immune cells from WT and Ptgs2-cKO mice
收藏Alliance of Genome Resources2026-08-01 收录
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To better understand the role of the COX-2-dependent lung fibroblast program in modulating the lung immune microenvironment, we generated fibroblast-targeted Ptgs2 conditional knockout (cKO) mice by crossing Pdgfra-Cre mice with Ptgs2flox/flox mice. Then we determined how Ptgs2 deficiency in CD140a+ fibroblasts alters the lung immune microenvironment by performing single-cell RNA sequencing on lung CD45+ immune cells from WT and Ptgs2-cKO mice. Lung CD45+ immune cells from WT and Ptgs2-cKO mice were isolated by Fluorescence-activated cell sorting (FACS) and analyzed using scRNAseq.
