VHL gene alterations among histologically confirmed RCC, clear cell RCC, and non-clear cell RCC cases.

RCC include clear cell, papillary, chromophobe cases. ccRCC includes clear cell, ccRCC with papillary features, and sarcomatoid differentiation.Non ccRCC includes papillary and chromophobe RCC cases.Any alteration group includes VHL inactivating and non-inactivating genetic alterations and promoter hypermethylation.Non functional genetic alteration group includes subjects without VHL inactivating alterations.Total number of mutation group lacks the location of two splices with unknown intron location.