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Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embyronic and induced pluripotent cells

ChEBI2013-06-01 更新2026-07-21 收录

细胞命运决定

Notch信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-47466 数据链接链接失效反馈

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Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embyronic and induced pluripotent cells

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创建时间：

2013-06-01

细胞命运决定

蛋白酶体调控

We show that lysosomes are antagonistically controlled by TFEB and MYC to balance catabolic and anabolic processes required for activating LT-HSC and guiding their lineage fate. TFEB-mediated inductio

NIAID Data Ecosystem80

Oncogenic Notch promotes long-range regulatory interactions within hyperconnected 3D cliques [Rec1_ChIP-seq]

癌症三维基因组学

Notch信号通路

Purpose: To investigate the impact of oncogenic Notch on the 3D genome organization of cancer cells. Methods: We generated cohesin HiChIP and 1D epigenomic data sets in two different Notch-dependent c

NIAID Data Ecosystem50

Paneth cells acquire multi-potency upon Notch activation after irradiation

细胞可塑性

Notch信号通路

In murine models, we find that irradiation of Paneth cells caused a gain of a stem cell-like transcriptome and induced activation of the Notch signaling pathway. This study documents plasticity by Pan

NIAID Data Ecosystem20

Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche

细胞信号传导

细胞命运决定

In the epithelial follicle stem cells (FSCs) of the Drosophila ovary, Epidermal Growth Factor Receptor (EGFR) signaling promotes self-renewal, whereas Notch signaling promotes differentiation of the p

DataONE2020-06-24 更新50

Transcriptional network governing extraembryonic endoderm cell fate choice

细胞命运决定

转录调控网络

The mechanism by which transcription factor (TF) network instructs cell-type-specific transcriptional programs to drive primitive endoderm (PrE) progenitors to commit to parietal endoderm (PE) versus

NIAID Data Ecosystem40

Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embyronic and induced pluripotent cells

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