Pre-steady state kinetic constants for binding and incorporation of dATP and TFV-DP by WT, K70Q, Q151Mc and K70Q/Q151Mc HIV-1 RT.
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a.Data are means ± standard deviations from at least three independent experiments. b.The sequence of HIV RT WT and mutant derived from BH10. c.Selectivity is defined as (kpol/Kd)dATP/(kpol/Kd)TFV-DP. d.Resistance (fold) is calculated as selectivity mutant/selectivity WT.
创建时间：
2011-01-13
