A cell cycle-regulated inhibitor of cyclin-dependent kinases.
收藏PubMed Central1994-06-07 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC43980/
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资源简介：
Cyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans. We report here the identification of a 28-kDa protein, p28Ick (inhibitor of cyclin-dependent kinase), that binds to and inhibits the kinase activity of preformed Cdk/cyclin complexes from human cells. p28 inhibitory activity fluctuates during the cell cycle with maximal levels in G1 and accumulates in G1- and G0-arrested cells. These results suggest that control of the G1/S transition may be influenced by a family of Cdk inhibitors that include p28Ick and the recently described inhibitors p21Cip1/Waf1/Cap20 and p16Ink4. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1994-06-07
