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Formal [3 + 2] Cycloadditions of Donor−Acceptor Cyclopropanes and Nitriles

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NIAID Data Ecosystem2026-03-06 收录
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Donor−acceptor cyclopropanes activated with Me3SiOTf cleave to reactive intermediates that can be efficiently intercepted by nitriles in a formal [3 + 2] dipolar cycloaddition reaction. Aliphatic, aromatic, and α,β-unsaturated nitriles are excellent reaction partners, giving synthetically useful 2H-3,4-dihydropyrrole cycloaddition products in high yield.

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2016-08-18
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