Garmultins A–G, Biogenetically Related Polycyclic Acylphloroglucinols from Garcinia multiflora

Garmultins A and B (1 and 2), two polycyclic polyprenylated acylphloroglucinols characterized by the coupling of two novel cages, 2,11-dioxatricyclo­[4.4.1.03,9]­undecane and tricyclo­[4.3.1.03,7]­decane, along with five biogenetically related analogues (3–7), were isolated from Garcinia multiflora. Their structures and absolute configurations were determined by extensive NMR analysis, X-ray crystallography, and electronic circular dichroism calculations. Three compounds were capable of inhibiting oncogene expression and inducing apoptosis in human erythroleukemia cells.