Assessment of the platelet transcriptome in patients with COVID-19 versus controls

To understand how COVID-19 alters the platelet transcriptome. Overall design: A cohort of eight hospitalized COVID-19 patients (n=8) were recruited from NYU Langone Health between May 11-21, 2020. SARS-CoV-2 infection was confirmed by RT-PCR, in accordance with current standards. All COVID-19 patients and , age-, and sex-matched control donors were recruited under study protocols approved by the NYU Langone Health Institutional Review Board. Each study participant or their Legal Authorized Representative gave written informed consent for study enrollment in accordance with the Declaration of Helsinki. For COVID-19 patients, enrollment criteria included age greater than 18, hospital admission, positive SARS-CoV-2 testing, and informed consent. COVID-19 patients were monitored until discharge or death.