Datasheet1_Short-term echocardiographic follow-up after hospitalization for COVID-19: a focus on early post-acute changes.pdf

BackgroundImpaired physical functional status is one of the typical long-term sequelae of COVID-19 infection that significantly affects the quality of life and work capacity. Minor changes in cardiac structure and function that are unable to cause the manifestation of overt heart failure may remain undetected in COVID-19 convalescents, at the same time potentially contributing to the persistence of symptoms and development of long COVID syndrome.PurposeTo study the typical features and short-term dynamics of cardiac remodeling and possible signs of cardiac dysfunction following hospitalization for COVID-19.MethodsThis is a combined cross-sectional and longitudinal cohort study in which 176 hospitalized patients (93 female and 83 male, mean age 53.4 ± 13.6 years) with COVID-19 infection underwent comprehensive transthoracic echocardiography pre-discharge (22.6 ± 7.1 days from the onset of symptoms) with repeated evaluation after 1 month. The control group included 88 age-, sex-, height- and weight-matched healthy individuals, with a subset of those (n = 53) matched to the subset of non-hypertensive study participants (n = 106).ResultsConcentric left ventricular geometry was revealed in 59% of participants, including 43% of non-hypertensive subjects; predominantly Grade I diastolic dysfunction was found in 35 and 25% of patients, respectively. Other findings were naturally following from described phenotype of the left venticle and included a mild increase in the absolute and relative wall thickness (0.45 ± 0.07 vs. 0.39 ± 0.04, p

背景：COVID-19感染后，背景受损的生理功能状态是常见的长期后遗症之一，它显著影响生活质量和工作能力。在COVID-19康复者中，即使心脏结构和功能发生微小变化，无法引起明显心力衰竭的表现，也可能未被察觉，同时可能有助于症状的持续和长期COVID综合症的发展。研究目的：研究COVID-19住院后典型的心脏重塑特征和短期动态变化，以及可能的心脏功能障碍迹象。方法：本研究是一项结合横断面和纵向队列研究，其中176名COVID-19感染住院患者（女性93名，男性83名，平均年龄53.4±13.6岁）在出院前接受了全面的经胸超声心动图检查（症状出现后22.6±7.1天），并在一个月后进行了重复评估。对照组包括88名年龄、性别、身高和体重匹配的健康个体，其中53名个体与106名非高血压研究参与者进行了子集匹配。结果：在59%的参与者中发现了同心性左心室几何形状，包括43%的非高血压受试者；在35%和25%的患者中发现了主要为一级舒张功能障碍。其他发现自然地遵循所描述的左心室表型，包括绝对和相对壁厚度的轻微增加（0.45±0.07 vs. 0.39±0.04，p