Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

Aberrant neurodevelopment in Down syndrome (DS)-caused by triplication of human chromosome 21-is commonly attributed to gene dosage imbalance, linking overexpression of trisomic genes with disrupted developmental processes, with DYRK1A particularly implicated. We hypothesized that regional brain DYRK1A protein overexpression in trisomic mice varies over development in sex-specific patterns that may be distinct from Dyrk1a transcription, and reduction of Dyrk1a copy number from 3 to 2 in otherwise trisomic mice reduces DYRK1A, independent of other trisomic genes. DYRK1A overexpression varied with age, sex, and brain region, with peak overexpression on postnatal day (P) 6 in both sexes. Sex-dependent differences were also evident from P15-P24. Reducing Dyrk1a copy number confirmed that these differences depended on Dyrk1a gene dosage and not other trisomic genes. Trisomic Dyrk1a mRNA and protein expression were not highly correlated. Sex-specific patterns of DYRK1A overexpression during t..., , , # Data from: Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

Hawley, L.E., M.E. Stringer, A. Parker, A. Folz, C.R. Goodlett, R.J. Roper. Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model. Science

This README file was generated on 2024-01-10 by Laura Hawley.

GENERAL INFORMATION

1\. Title of Dataset: Data from: Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

2\. Author Information

A. Principal Investigator Contact Information

Name: Randall Roper

Institution: Indiana University Purdue University Indianapolis

Address: Indianapolis, IN USA

Email: [e-mail]

3\. Date of data collection (single date, range, approximate date): January 2027 – June 2022

4\. Geographic location of data collection: Indianapolis, Indiana

5\. Information about funding sources that supported the collection of the data: ...