Targeted protein degradation refers to the use of small molecule protein-protein dimerizers that recruit a ubiquitin E3 ligase to a protein of interest for chemically induced degradation. Here we comb
Malaria, caused by Plasmodium parasites, results in >400,000 deaths annually. There is no effective vaccine, and new drugs with novel modes of action are needed because of increasing parasite resistan
Additional file 3. Table S1: K-M analysis findings for OS, PFS, DFS and DSS were aggregated across 33 cancer types according to the HDACs expression level.
The different worksheets show results obtained by DESeq2 analysis for JQ12 or MS-275 treated wildtype cells, HDAC1-3 catalytic inactive mutants expressed in wildtype and corresponding KOs, and HDAC3 K
