CROHN'S DISEASE AND OXALATE NEPHROLITHIASIS: A PATHOPHYSIOLOGICAL AND NUTRITIONAL GUIDE

Key takeaways: Crohn’s disease, significantly increases the risk of oxalate kidney stones due to fat malabsorption and altered intestinal barrier function. Gut inflammation, bowel resection, and microbiota changes (e.g., loss of Oxalobacter formigenes) further impair oxalate metabolism and excretion. Low urine volume, low citrate, and acidic pH in IBD patients create a high-risk environment for calcium oxalate crystal formation. Dietary management—including low-oxalate foods, adequate hydration, calcium intake with meals, and limiting fat—is crucial for prevention.