ABE8e. Homo sapiens strain:HEK293T

NIAID Data Ecosystem2026-03-11 收录

碱基编辑器优化

CRISPR-Cas工程

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA589228 数据链接链接失效反馈

官方服务：

资源简介：

Continuous evolution of an adenine base editor with enhanced Cas domain compatibility and activity

创建时间：

2019-11-13

Increase base editing efficiency and product variety through fusion of Cas9 nickase to cytosine and adenosine deaminases

基因编辑技术

碱基编辑器优化

Base editors, which are created through fusion of Cas9 nickase to either cytidine or adenine deaminase, efficiently catalyze site-specific nucleotide conversions with minimal indel rates. However, cyt

NIAID Data Ecosystem60

miniature base editors

基因编辑

碱基编辑器优化

To generate miniature cytosine and adenine base editors (miniCBEs and miniABEs) with expanded editing scopes and improved safety

NIAID Data Ecosystem40

Two hyper base editors: hyABE with increased A-to-G efficiency towards PAM and hyA&C-BEmax with substantially improved A/C simultaneous conversion efficiency.

碱基编辑器优化

基因编辑效率

Base editors, mainly including cytidine base editors(CBE) and adenine base editors(ABE), have been widely used to modify single-base in genomic DNA. The efficiency of A-to-G towards the PAM for ABE an

NIAID Data Ecosystem30

Cas12a base editors induce efficient and specific editing with low DNA damage response

CRISPRi基因编辑

碱基编辑器优化

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem60

Increasing efficiency and targeting scope of base editors through fusion of a single strand DNA binding protein domain

碱基编辑器优化

基因治疗模型

Cytidine base editors (CBEs) are powerful genetic tools which catalyze cytidine to thymidine conversion at specific genomic loci. However, the current CBEs are not very efficient especially for the pu

NIAID Data Ecosystem40

ABE8e. Homo sapiens strain:HEK293T

资源简介：

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