TEAD functions as a conserved master regulator of DNA repair systems: Implications for cancer immunotherapy

This dataset accompanies the manuscript “TEAD functions as a conserved master regulator of DNA repair systems: Implications for cancer immunotherapy.” We hypothesize that TEAD transcription factors coordinate DNA-repair programs and that TEAD1/4 perturbation reshapes genome instability and tumor immunogenicity. The dataset includes multi-omics and molecular profiling resources generated in mouse colorectal cancer CT26 cells: TEAD CUT&Tag peak identification (Table 1), RNA-seq transcriptional profiling of Tead1/4 double-KO versus parental cells (Table 2), curated TEAD1/4 target genes (Table 3), TEAD1/4-associated proteins identified by mass spectrometry (Table 4), RNA-seq after Setd1a knockdown (Table 5), ATAC-seq chromatin accessibility landscapes (Table 6), and lists of novel nonsynonymous SNVs/indels and NetMHCcons-predicted neoantigens in Tead1/4 double-KO cells (Tables 7–8). RNA sequence information (siRNA and primer sequences) is provided (Tables 9–10). These files enable integrative analysis of TEAD-dependent chromatin regulation, transcription, protein interactions, and mutation/neoantigen consequences relevant to immunotherapy.