Circ_0020123 promotes NSCLC tumorigenesis via up-regulating KIAA1522 expression through miR-940
收藏Taylor & Francis Group2024-07-04 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/Circ_0020123_promotes_NSCLC_tumorigenesis_via_up-regulating_KIAA1522_expression_through_miR-940/19222969
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资源简介：
Circ_0020123 was highly expressed in NSCLC tissues and cell lines, and knockdown of circ_0020123 abolished cell growth, migration and invasion <i>in vitro</i> and hindered tumor growth in nude mice. Mechanically, circ_0020123 directly targeted miR-940, and KIAA1522 was a target of miR-940. Thereafter, a series of rescue experiments showed that circ_0020123 served its biological functions by miR-940/KIAA1522 axis. In all, circ_0020123 acted as an oncogene to promote the tumorigenesis of NSCLC via miR-940/KIAA1522 axis, suggesting a potential therapeutic target for NSCLC treatment.
提供机构：
Zhou, Xiaomei; Shi, Minxin; Wang, Qing; Zheng, Liyun; Ju, Guanjun; Xiao, Ting; Chen, Jian; Chen, Saihua; Fan, Yihui; Lu, Haimin
创建时间：
2022-02-23
