Table S6. Top enrichment results of age-associated differentially hypermethylated CpG positions (aDMPs) for age-related diseases and quantitative traits. (XLSX 12 kb)

Figshare2019-08-19 更新00

DOT1L controls NK cell maturation and lineage integrity [RNA-seq D0 & D2]. DOT1L controls NK cell maturation and lineage integrity [RNA-seq D0 & D2]

细胞免疫学

表观遗传学

Epigenetic modifiers are promising targets to improve therapies in patients with cancer. Targeting the methyltransferase DOT1L with small molecule inhibitors has shown promising effects on the control

NIAID Data Ecosystem40

Hypo-acetylated Genes of Mouse Clone (C1)

表观遗传学

ChIP-qPCR

The change in acetylation is displayed as both percent change (%) and log (base2) values for the C1 animal relative to D1. Each value represents the average of two replicates ChIP-qPCR assays.

NIAID Data Ecosystem30

Loss of epigenetic regulation disrupts lineage commitment and promotes breast cancer

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