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First Enantioselective Total Synthesis of (+)‑(<i>R</i>)‑Pinnatolide Using an Asymmetric Domino Allylation Reaction

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NIAID Data Ecosystem2026-03-07 收录
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An efficient total synthesis of (+)-(R)-Pinnatolide is described. As a key step an asymmetric multicomponent domino allylation reaction of methyl levulinate is used to form the quaternary stereogenic center in a highly selective way.

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2012-08-17
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