Supplementary tables: Healthcare and economic burden of anticholinergic use in adults with overactive bladder: a systematic literature review

These are peer-reviewed supplementary materials for the article 'Healthcare and economic burden of anticholinergic use in adults with overactive bladder: a systematic literature review' published in the Journal of Comparative Effectiveness Research.Supplementary Table 1: Search strategySupplementary Table 2: Quality evaluation of observational studiesSupplementary Table 3: Quality evaluation of economic studiesSupplementary Table 4: Detailed reporting of HCRU outcomesSupplementary Table 5: Detailed reporting of cost outcomesAim: To determine the economic burden associated with anticholinergic medication use in adults with overactive bladder (OAB) in the USA. Methods: A systematic literature review was conducted to identify articles assessing healthcare resource utilization (HCRU) and costs associated with anticholinergic use in adults with OAB. Results: From the 34 articles identified, increased anticholinergic burden, switching anticholinergic treatments and potentially inappropriate anticholinergic use were associated with increased HCRU and/or costs. However, studies comparing patients with OAB receiving anticholinergics to individuals with untreated OAB or without OAB reported a mix of increases and decreases in HCRU and costs. Conclusion: Additional controlled studies assessing the economic impact of anticholinergics in OAB are needed and may enable optimization of economic and potentially patient outcomes.

本数据集为发表于《比较疗效研究杂志》的论文《成人过度活跃膀胱患者抗胆碱能药物使用的医疗和经济负担：一项系统文献综述》的同行评审补充材料。补充表格1：检索策略；补充表格2：观察性研究的质量评估；补充表格3：经济研究的质量评估；补充表格4：HCRU（抗胆碱能药物使用相关的医疗资源利用）结果的详细报告；补充表格5：成本结果的详细报告。研究目标：确定美国成人过度活跃膀胱（OAB）患者使用抗胆碱能药物的经济负担。研究方法：通过系统文献综述，识别评估成人OAB患者抗胆碱能药物使用相关的医疗资源利用（HCRU）和成本的文章。研究结果：在识别的34篇文章中，抗胆碱能药物负担的增加、抗胆碱能药物治疗的转换以及可能的不适当使用与医疗资源利用（HCRU）和/或成本的上升相关。然而，比较接受抗胆碱能药物治疗的OAB患者与未接受治疗的OAB患者或无OAB患者的多项研究结果显示，医疗资源利用（HCRU）和/或成本有升有降。研究结论：需要更多对照研究来评估抗胆碱能药物在OAB中的经济影响，这可能有助于优化经济和潜在的病人结果。