Per-cell heritability scores and cell metadata for: Cardiac pacemaker cells carry common-variant heritability for human cognitive traits but not for ventricular repolarization

Per-cell heritability scores and cell metadata Derived data for Cardiac pacemaker cells carry common-variant heritability for human cognitive traits but not for ventricular repolarization. Analysis code, pre-registered predictions and all summary result tables are in the companion software archive; this record holds only the large per-cell matrices that the code consumes and produces. Every file is tab-separated. Score files carry one row per cell with the columns emitted by scDRS: index, raw_score, norm_score, mc_pval, pval, nlog10_pval, zscore. The analysis uses norm_score. No raw data are redistributed here. The human atlas, the mouse dataset and every GWAS are public and are identified by accession in the manuscript and in the software archive's DATA-SOURCES.md. Contents scdrs_conduction_axis_scores.zip Per-cell scDRS scores for the conduction-axis dataset (78,134 nuclei, 76 cell states, 22 donors, 8 regions). One file per trait; *_lenadj files are the gene-length-adjusted rebuilds. 35 files, 274.2 MB uncompressed. AtrialFibrillation.score.tsv AtrialFibrillation_lenadj.score.tsv AtrialFlutter.score.tsv AtrialFlutter_lenadj.score.tsv AVblock.score.tsv AVblock_lenadj.score.tsv Brugada.score.tsv Brugada_lenadj.score.tsv BundleBranchBlock.score.tsv BundleBranchBlock_lenadj.score.tsv EducationalAttainment.score.tsv EducationalAttainment_lenadj.score.tsv HeartFailure.score.tsv HeartFailure_lenadj.score.tsv HRV_RMSSD.score.tsv HRV_RMSSD_lenadj.score.tsv HRV_RMSSDc.score.tsv HRV_RMSSDc_lenadj.score.tsv HRV_SDNN.score.tsv HRV_SDNN_lenadj.score.tsv HRV_SDNNc.score.tsv HRV_SDNNc_lenadj.score.tsv Intelligence.score.tsv PRinterval.score.tsv PRinterval_lenadj.score.tsv QRSduration.score.tsv QRSduration_lenadj.score.tsv QTinterval.score.tsv QTinterval_lenadj.score.tsv ReactionTime.score.tsv RestingHeartRate.score.tsv RestingHeartRate_lenadj.score.tsv RheumatoidArthritis.score.tsv RheumatoidArthritis_lenadj.score.tsv RheumatoidArthritis_noMHC.score.tsv scdrs_nodal_scores.zip Per-cell scDRS scores for the nodal dataset (118,172 cells, all 10x multiome, so global rankings within it are not confounded by assay). 17 files, 233.9 MB uncompressed. AtrialFibrillation.score.tsv AtrialFlutter.score.tsv AVblock.score.tsv Brugada.score.tsv BundleBranchBlock.score.tsv EducationalAttainment.score.tsv HeartFailure.score.tsv HRV_RMSSD.score.tsv HRV_RMSSDc.score.tsv HRV_SDNN.score.tsv HRV_SDNNc.score.tsv PRinterval.score.tsv QRSduration.score.tsv QTinterval.score.tsv RestingHeartRate.score.tsv RheumatoidArthritis.score.tsv RheumatoidArthritis_noMHC.score.tsv scdrs_mouse_scores.zip Per-cell scDRS scores for mouse embryonic day 16.5 conduction zones (GSE132658). *_disjoint files are scored on the gene sets remaining after deleting the union of all cardiovascular sets. 11 files, 10.9 MB uncompressed. EducationalAttainment.score.tsv EducationalAttainment_disjoint.score.tsv HRV_RMSSD.score.tsv HRV_SDNN.score.tsv Intelligence.score.tsv Intelligence_disjoint.score.tsv QTinterval.score.tsv ReactionTime.score.tsv ReactionTime_disjoint.score.tsv RestingHeartRate.score.tsv RheumatoidArthritis.score.tsv cell_metadata.zip Cell metadata for both human datasets: cell barcode, cell state, donor, region, assay chemistry and cell type. These define the strata (donor x region x chemistry) of the primary statistic. 2 files, 17.9 MB uncompressed. obs_axis.tsv obs_node.tsv Integrity SHA-256 of each archive: 13c4bfa5df3f19d952fbb7ade8cc737a3d8d1d507787fb525cb890bf8ece2ca0 scdrs_conduction_axis_scores.zip 5935330f77fcac223adb29bfb10df13da023ef2136499fc4e99647b41fea6b62 scdrs_nodal_scores.zip ae8f6031dd39839b38fa43e2942d1ebc974067dd7209fe803c7d8b70ce76d437 scdrs_mouse_scores.zip 93ab9d2302ec79dae95949a056351bab84650f78083d3073fe12417f132c800d cell_metadata.zip