Association of the genetic risk score with BMI and risk of obesity adjusted for age, age2, and sex in the combined sample of all 11 cohorts and further stratified by physical activity level.

aPhysical activity was estimated according to the Cambridge Physical Activity Index (CPAI), which categorizes total physical activity levels on a four level scale.bIncrease in BMI units (kg/m2) for each additional unit increase in the GRS (equivalent to one additional risk allele).cβ converted to body weight (g) for a person 1.70 m tall.dhigher odds of being obese (≥30 kg/m2) versus normal weight (18.5≤BMI2) for each additional BMI-increasing allele.