De novo identified motifs and their conservation between pathways and species.

We tested the reference motif list for pathway conservation and between species conservation. For each motif, we computed the enrichment in known TFBSs databases and reported the corresponding significant TFs. It appears that several TFs may be acting cooperatively to regulate the expression of cyclic genes. We also noticed motif conservation between mouse and chicken as opposed to zebrafish where any of the discovered motifs could be found in the promoters of known cyclic genes. The conservation between species is given in terms of percentage of reported cyclic genes of the species with the corresponding motif in their promoter region.