Data from: Diagnostic accuracy of presepsin in predicting bacteremia in elderly patients admitted to the emergency department: prospective study in Japan

Objective Early detection of bacteremia in the elderly is needed in the
emergency department (ED). Design, Setting, and Participants Prospective
study in Japan, single center trial in patients who satisfied the sepsis
criteria was conducted between September 2014 and March 2016. Forty-six
elderly patients aged ≥70 years were included. Interventions Blood
sampling to evaluate C-reactive protein (CRP), procalcitonin (PCT) and
presepsin plasma levels; two sets of blood sampling for bacterial
cultures; and evaluations of the Sequential Organ Failure Assessment
(SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE II)
scores were performed upon arrival at the ED. The results were compared
between patients with bacteremia and those without bacteremia. Main
Outcome Measure The accuracy of detecting bacteremia Results The presepsin
value was significantly higher in the bacteremia group than in the
non-bacteremia group (866.6 ± 184.6 pg/mL vs. 639.9 ± 137.1 pg/mL, p =
0.03). The PCT and CRP did not significantly differ between the groups.
The area under the receiver-operating-characteristic curve (AUC) values
were not significantly different among presepsin (0.69), PCT (0.61), and
CRP (0.53). Multivariate analysis showed that presepsin was independently
associated with bacteremia (odds ratio, 8.84; 95% confidence interval,
0.95–81.79; p = 0.02). Conclusion Presepsin could be a good biomarker to
predict bacteremia in elderly patients with sepsis criteria admitted to
the ED.