EGFR Exon20 insertion mutant NPG bound with STX-721

EGFR Exon20 insertion mutant NPG bound with STX-721 Descriptor: (2R,3S)-3-[(3-chloranyl-2-methoxy-phenyl)amino]-2-[3-[2-[(2R)-1-[(E)-4-(dimethylamino)but-2-enoyl]-2-methyl-pyrrolidin-2-yl]ethynyl]pyridin-4-yl]-1,2,3,5,6,7-hexahydropyrrolo[3,2-c]pyridin-4-one, 1,2-ETHANEDIOL, Epidermal growth factor receptor, ... Authors: Hilbert, B.J, Brooijmans, N, Milgram, B.C, Pagliarini, R.A. Deposit date: 2024-08-27 Release date: 2025-05-14 Last modified: 2025-07-23 Method: X-RAY DIFFRACTION (1.632 Å) Cite: STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models. Clin.Cancer Res., 31, 2025