Ruthenium(II)–Arene RAPTA Type Complexes Containing Curcumin and Bisdemethoxycurcumin Display Potent and Selective Anticancer Activity
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https://figshare.com/articles/dataset/Ruthenium_II_Arene_RAPTA_Type_Complexes_Containing_Curcumin_and_Bisdemethoxycurcumin_Display_Potent_and_Selective_Anticancer_Activity/2036940
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资源简介：
A series of novel ruthenium(II) arene
RAPTA type derivatives (arene
= cymene, hexamethylbenzene) containing curcumin-based ligands (curcH
= curcumin, bdcurcH = bisdemethoxycurcumin) and PTA (1,3,5-triaza-7-phosphaadamantane)
have been synthesized and fully characterized. The solid-state structures
of [Ru(cym)(curc)(PTA)][SO3CF3], [Ru(hmb)(curc)(PTA)][SO3CF3], and [Ru(hmb)(bdcurc)(PTA)][SO3CF3] have been determined by single-crystal X-ray diffraction.
The antitumor activity of the complexes has been evaluated in vitro
against human ovarian carcinoma cells (A2780 and A2780cisR), as well
as against nontumorous human embryonic kidney (HEK293) cells. The
correlation of the cytotoxicity upon switching the curcumin-based
ligands, i.e. curcumin vs bisdemethoxycurcumin, is not straightforward.
In contrast, the PTA ligand greatly enhances the activity and selectivity
of ruthenium compounds in comparison to previously reported compounds.
创建时间：
2015-12-17
