DNA methylation profile of Tasmanian Devil facial tumor biopsies and matched healthy skin and spleen samples, as well as additional nerve tissue, and strain 1 tumor cell line.
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE108160
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资源简介：
Purpose: Depict the landscape of epigenetic regulation in Tasmanian devil facial tumor biopsies. Differential analysis of healthy versus tumor biopsies highlighted 166 candidate genes with different DNA methylation levels in their promoters, which included the tumor-specific hypermethylated promoters of Estrogen Receptor 1 (ESR1) and the transcription factor GATA3. We mapped DNA methylation by reduced representation bisulfite sequencing and analysed epigenetic heterogeneity between healthy and tumor biopsies.
创建时间：
2019-02-20
