Creb overexpression induces leukemia in zebrafish by blocking myeloid differentiation process
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE71270
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资源简介：
To examine the role of CREB overexpression in hematopoiesis, we created a model of leukemia in zebrafish by overexpressing the human CREB in the myeloid hematopoietic lineage. Whole transcriptome analysis of kidney-marrow revealed 171 genes differently expressed between CREB- and control-zebrafish (five per group). Interestingly, the integration of this signature with human deposited data revealed that this tumor resembled a human AML at transcriptome level. Gene expression analysis of kidney marrow from CREB-zebrafish and zebrafish controls (five animals per group).
创建时间：
2018-01-25
