Venn diagram of the exclusive and shared genera of Bangladeshi and U.S. children based on V1–V3 16S rDNA sequence data.

The G test of independence was used to determine whether genus presence or absence was associated with one group of children or the other. A list of the most significant genera was compiled based on FDR-corrected p-values. Furthermore, to qualify for a specific country group, the genus had to be observed ≥5 times for each time point within an individual and within all individuals in a country group. The genera exclusively found in Bangladeshi or U.S. children are outlined in red and blue, respectively. The overlapping area between the two groups represents the genera that are shared by all individuals from both countries. The size of each enclosed area is directly proportional to the number of genera that are found in each group. The genera are colored-coded according to the list of phyla on the right. Only U.S. children and Bangladeshi children were included in this analysis.