MITF WT and K243-mutant binding and expression [ChIP-Seq]

MITF is the master regulator of the melanocyte lineage and a melanoma lineage oncogene. It controls a wide range of target genes fulfilling many distinct functions, but relatively little is known about how its DNA-binding is regulated to select the correct target genes. The datasets presented here were used investigate the effects of MAPK signaling-induced MITF-acetylation on MITF activity in melanoma cells through ChIP-Seq of wild-type and acetyl-mutant MITF. Overall design: 8 samples corresponding to WT and mutant MITF ChIP-Seq profiles in 501mel cells. Anti-HA ChIP-Seq in 501mel cells expressing empty vector was used as a control.