Gut microbiota in Parkinson's disease: temporal stability and disease progression. Parkinson's disease gut microbiota follow-up

Aiming to explore the temporal stability of gut microbiota in Parkinson's disease and the potential relationship of microbiota and disease progression, we characterized the gut bacterial communities of 64 Parkinson's patients and 64 control subjects from two stool samples per subject, collected on average 2.25 years apart. Microbial communities were analyzed with amplicon sequencing of the V3-V4 variable regions of the 16S rRNA gene, performed on the Illumina MiSeq platform.