Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534
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Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534 Descriptor: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Tyrosine-protein kinase ABL1 Authors: Zhou, T, Huang, W.S, Wang, Y, Thomas, M, Keats, J, Xu, Q, Rivera, V, Shakespeare, W.C, Clackson, T, Dalgarno, D.C, Zhu, X. Deposit date: 2010-09-22 Release date: 2010-12-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance. Chem.Biol.Drug Des., 77, 2011
创建时间：
2010-09-22
