peptides_nonfouling

## Dataset Details

### Dataset Description

Non-fouling is defined as resistance to non-specific interactions.
A non-fouling peptide (positive example) is defined using the mechanism proposed in
ref white2012decoding. Briefly, ref white2012decoding, showed that the exterior surfaces
of proteins have a significantly different frequency of amino acids, and this increases
in aggregation prone environments, like the cytoplasm. Synthesizing self-assembling peptides
that follow this amino acid distribution and coating surfaces with the peptides creates
non-fouling surfaces. This pattern was also found inside chaperone proteins,
another area where resistance to non-specific interactions is important (ref white2012role).

- **Curated by:**
- **License:** CC BY 4.0

### Dataset Sources

- [corresponding publication](https://doi.org/10.1021/acs.jcim.2c01317)
- [data source](https://doi.org/10.18653/v1/K18-1030)

## Citation

<!-- If there is a paper or blog post introducing the dataset, the APA and Bibtex information for that should go in this section. -->

**BibTeX:**

```bibtex
@article{white2012decoding,
title={Decoding nonspecific interactions from nature},
author={White, Andrew D and Nowinski, Ann K and Huang, Wenjun and Keefe,
Andrew J and Sun, Fang and Jiang, Shaoyi},
journal={Chemical Science},
volume={3},
number={12},
pages={3488--3494},
year={2012},
publisher={Royal Society of Chemistry}
@article{barrett2018classifying,
title={Classifying antimicrobial and multifunctional peptides with Bayesian network models},
author={Barrett, Rainier and Jiang, Shaoyi and White, Andrew D},
journal={Peptide Science},
volume={110},
number={4},
pages={e24079},
year={2018},
publisher={Wiley Online Library}
```

# 数据集详情
## 数据集描述
抗非特异性吸附（non-fouling）被定义为对非特异性相互作用的抵抗能力。抗非特异性吸附肽（阳性样本，positive example）的定义依据文献white2012decoding中提出的机制。简言之，该文献指出，蛋白质的外表面氨基酸组成频率存在显著差异，且在细胞质等易聚集的环境中这种差异更为突出。遵循该氨基酸分布规律合成的自组装肽，经表面涂布后即可制备得到抗非特异性吸附表面。这一氨基酸模式同样存在于伴侣蛋白内部——而伴侣蛋白是另一类需要抵抗非特异性相互作用的场景（参考文献white2012role）。

- **整理者：**
- **授权协议：** CC BY 4.0

## 数据集来源
- [对应研究论文](https://doi.org/10.1021/acs.jcim.2c01317)
- [数据源](https://doi.org/10.18653/v1/K18-1030)

## 引用
<!-- 若有介绍该数据集的论文或博文，此处应填入其APA格式与BibTeX格式引用信息。 -->

**BibTeX引用：**
bibtex
@article{white2012decoding,
title={解码自然中的非特异性相互作用},
author={White, Andrew D and Nowinski, Ann K and Huang, Wenjun and Keefe,
Andrew J and Sun, Fang and Jiang, Shaoyi},
journal={Chemical Science},
volume={3},
number={12},
pages={3488--3494},
year={2012},
publisher={Royal Society of Chemistry}
@article{barrett2018classifying,
title={利用贝叶斯网络模型分类抗菌与多功能肽},
author={Barrett, Rainier and Jiang, Shaoyi and White, Andrew D},
journal={Peptide Science},
volume={110},
number={4},
pages={e24079},
year={2018},
publisher={Wiley Online Library}