Asymmetric Hydrogenation of Tetrasubstituted Cyclic Enones to Chiral Cycloalkanols with Three Contiguous Stereocenters
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https://figshare.com/articles/dataset/Asymmetric_Hydrogenation_of_Tetrasubstituted_Cyclic_Enones_to_Chiral_Cycloalkanols_with_Three_Contiguous_Stereocenters/5053885
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资源简介：
A highly efficient
iridium-catalyzed asymmetric hydrogenation of
tetrasubstituted cyclic enones has been developed for the enantioselective
synthesis of chiral cycloalkanols with three contiguous stereocenters.
The CO and CC bonds of the enone substrates were hydrogenated
sequentially in one pot with excellent enantioselectivity (92 to >99%
ee) and diastereoselectivity (dr 95:5 to >99:1). The reaction provided
a practical approach to all of the stereoisomers of the antiulcer
drug rosaprostol.
创建时间：
2017-05-31
