Crystal structure of menin in complex with inhibitor compound 26

Crystal structure of menin in complex with inhibitor compound 26 Descriptor: (1R,5R)-2-({5-fluoro-2-[(5-{7-[(1-methylcyclopropyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl}-1,2,4-triazin-6-yl)oxy]phenyl}methyl)-2-azabicyclo[3.1.0]hexan-3-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Menin, ... Authors: Bester, S.M, Wu, W.-I, Mou, T.-C. Deposit date: 2024-06-13 Release date: 2025-01-15 Last modified: 2025-03-05 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Design of Potent Menin-KMT2A Interaction Inhibitors with Improved In Vitro ADME Properties and Reduced hERG Affinity. Acs Med.Chem.Lett., 16, 2025