SND1 is a novel regulator of endothelial function

Staphylococcal nuclease and tudor domain containing protein 1 (SND1), which is also known as p100 or Tudor-SN, is a recently identified protein that is highly expressed in multiple cancers including breast cancer, liver cancer, and colon cancer. Endothelial function and vascular integrity are critical modulators in cancer metastasis and progression. Although much progress has been made in studying SND1's oncogenic role, the involvement of SND1 in endothelial function has never been explored. Overall design: Comparative gene expression profiling analysis of RNA-seq data for three lines of hiPSC-EC transfected with either scramble shRNA or SND1 shRNA for 48 hours.