Genetic variants in the hepatic uptake transporter OCT1, observed in 9% of Europeans and white Americans, are known to affect pharmacokinetics and efficacy of tramadol, morphine, and codeine. Here, we
n = number of fish in each category. Damage scale: A = All hair cells of the neuromast appear normal. B = Slight mitochondrial swelling (modest within range of mock-treated controls). C = One or more
Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype–phenotype relationships in human cells, including searches fo
Relevance: The gut microbiome and genetic factors contribute to OUD-related phenotypes, including oxycodone-induced analgesia and reward. Here, we examine the effects of genetic background and oxycodo
