Association between SNP-43 and SNP-44 of the CAPN10 gene and calpain-10 mRNA expression, glucose-, arginine- and glibenclamide-stimulated insulin secretion in human non-diabetic pancreatic islets cultured in vitro.

Basal insulin secretion is analysed when culturing islets in 5.5 mmol/l glucose. Glucose stimulated insulin secretion (GSIS) is analysed after culturing islets in 16.7 mmol/l glucose for 45 min as described in the method section.1µU/islet/minutes. SI is the insulin stimulation index i.e. incremental folds above baseline insulin release. Results are mean±SEM with number of individuals shown in parentheses.2For a dominant model. P values are not corrected for multiple testing.